🔬Generating Molecules, Not Just Models
Feb 12, 2026 · 1:41:26
Gabriele Corso and Jeremy Wolwen, founders of Boltz, explain how their open-source models democratize biomolecular structure prediction and design, building on AlphaFold2's breakthrough in single-chain protein folding to model interactions with small molecules, RNA, and DNA. They recount how, after AlphaFold3 was kept closed by DeepMind, they built Boltz1 in months by training a single large model with mid-training bug fixes and limited compute. The conversation covers the shift from regression to generative diffusion models, the critical role of evolutionary multiple sequence alignments (MSAs), and the specialized pairwise triangular attention architecture that remains central. They detail Boltz2's addition of affinity prediction and BoltzGen's unified sequence-structure diffusion for designing proteins, nanobodies, and peptides, validated across 25 labs on targets with no known interactions. Boltz Lab provides an API and interface with optimized inference (10× faster small-molecule screening) and collaborative ranking tools, aiming to serve academia, startups, and enterprises while keeping core models open.
