OpenRouter

Anthropic, Glean & OpenRouter: How AI Moats Are Built with Deedy Das of Menlo Ventures

Nov 14, 2025 · 1:26:59

Deedy Das of Menlo Ventures returns to explain how Anthropic became the fastest-growing software company ever (zero to billions in revenue) and why Glean’s boring enterprise search moat of hard integrations and ranking problems is harder than competitors think. He reveals the $100M Anthology Fund’s strategy: backing OpenRouter, Goodfire, Prime Intellect, and Whisper—companies that solve thorny infrastructure or research problems rather than chasing apps. Das argues that model-layer companies will capture most value because building great models is harder than building apps, and that Anthropic’s product innovations like Claude Code emerge from a culture that lets researchers experiment freely. He also warns that vibe coding is becoming a cognitive crutch for engineers, eroding deep problem-solving skills, and discusses how enterprise AI market share has shifted dramatically: OpenAI went from 50% to 20%, while Anthropic rose from 12% to 32% of enterprise LLM API spend.

GPT 4.1: The New OpenAI Workhorse

Apr 15, 2025 · 45:04

OpenAI's Michelle Pokrass and Josh McGrath join hosts Alessio, Swyx, and Sean to launch GPT 4.1, a new model family positioned as the go-to workhorse for developers with major improvements in coding, instruction following, and long context. The three models—4.1, 4.1 Mini, and 4.1 Nano—introduce a 1M-token context window, 75% prompt caching discount, and cheaper pricing than 4o. Coding gains are highlighted by 55% on SWE-bench (vs o1's 41%), while instruction following benefits from real-world API data and new evals like GraphWalk for multi-hop reasoning. The team explains that most improvements come from post-training techniques, with vision capabilities lifted by a new pre-trained base. Fine-tuning is available day one, and developers are encouraged to opt in to data sharing for future model iterations.